“The reason edibles can hit much harder and induce a more pronounced psychoactive effect is that the shape of 11-hydroxy THC allows it to pass through the blood-brain barrier more easily than delta-9 THC. Additionally, the molecule binds more strongly to the brain’s cannabinoid receptors. The stronger the bond to the CB1 receptor, the greater the activation of that receptor. With more 11-hydroxy THC molecules present in the bloodstream, more receptors are activated, leading to increased neurotransmitter release in the brain, which is responsible for cannabis’ psychoactive effects.”